Fig. 1
MCE detection of abnormal perfusion during vasodilator stress in HCM subjects. A Percentage of subjects with transmural diffuse, subendocardial or patchy, or normal perfusion during regadenoson for hypertrophied and non-hypertrophied control regions. B Example of end-systolic MCE images (apical 4-chamber) and corresponding time-intensity curves during vasodilator stress illustrating a patchy perfusion defect of the hypertrophied septum (arrows) and both reduced microvascular flux rate (β) and MBV (A-value). Images are shown immediately after microbubble destruction (T0) and at 3.2 s after refill (T3.2). C Vasodilator MCE (4-chamber view) illustrating delayed refill in all myocardial segments that was worse in the subendocardium. D Vasodilator MCE (4-chamber view) > 5 s after refill illustrating a transmural severe defect of the non-hypertrophied lateral wall (arrows)