Table 1 Baseline characteristics of participants
Normal diastolic function (E/e’mean < 8) n = 30 | With evidence of diastolic LV dysfunction (E/e’mean ≥ 8 & LAVmax ≥ 34 mL/m2) n = 26 | p-value | |
|---|---|---|---|
Anthropometry | |||
Women [%] | 4 (13 %) | 10 (38 %) | 0.07 |
Age [yrs] | 52.3 ± 15.1 | 64.8 ± 9.3 | 0.001 |
Weight [kg] | 76.5 ± 9.7 | 78.3 ± 12.8 | 0.63 |
Height [m] | 1.76 ± 0.07 | 1.71 ± 0.08 | 0.02 |
Body mass index [kg/m2] | 24.7 ± 2.6 | 26.7 ± 3.7 | 0.01 |
Fat Free Mass [kg] | 63.0 ± 9.5 | 57.2 ± 6.8 | 0.09 |
Body surface area [m2] | 1.92 ± 0.14 | 1.90 ± 0.18 | 0.55 |
Cardiovascular Risk Factors | |||
Hypercholesterolemia (total cholesterol ≥6.21 mmol/L) | 5 (17 %) | 7 (27 %) | 0.61 |
RRsys/RRdia | 128 ± 16/83 ± 10 | 144 ± 22/85 ± 9 | 0.01/0.25 |
Hypertension (RRsys > 140 mmHg or RRdia > 90 mmHg) | 9 (30 %) | 16 (62 %) | 0.07 |
Echocardiography | |||
Heart rate [bpm] | 59 ± 11 | 68 ± 10 | 0.001 |
3D-EFLV [%] | 59.7 ± 5.2 | 60.6 ± 12.0 | 0.14 |
LV mass [g/m2] | 86.6 ± 16.0 | 96.9 ± 30.4 | 0.35 |
E [cm/s] | 68.4 ± 18.1 | 79.6 ± 16.4 | 0.02 |
Left ventricle internal diameter, diastole [mm] | 47 ± 6 | 39 ± 11 | 0.002 |
Posterior wall thickness, diastole [mm] | 11 ± 2 | 13 ± 3 | <0.001 |
Septum wall thickness, diastole [mm] | 11 ± 2 | 14 ± 3 | <0.001 |
A [cm/s] | 60.6 ± 14.5 | 79.2 ± 20.0 | 0.001 |
E/A ratio | 1.20 ± 0.44 | 1.05 ± 0.35 | 0.10 |
Dct [ms] | 218 ± 8 | 262 ± 6 | 0.004 |
e’lat [cm/s] | 14.0 ± 3.6 | 8.9 ± 2.7 | <0.001 |
E/e’lat | 5.01 ± 1.12 | 9.9 ± 4.6 | <0.001 |
e’med [cm/s] | 9.3 ± 2.8 | 6.4 ± 1.5 | 0.001 |
E/e’med | 7.42 ± 1.57 | 13.01 ± 3.46 | <0.001 |
E/e’ mean | 5.55 ± 1.33 | 11.30 ± 2.92 | <0.001 |
E/e’ mean [range] | 2.9–7.9 | 8.0–20.0 | <0.001 |