Table 2 The primary, secondary endpoints and other characteristics of the imaging tests

 WMSI at stress during DSE

1.6 ± 0.4

1.4 ± 0.4*

1.4 ± 0.3*

1.6 ± 0.4

1.5 ± 0.3

1.4 ± 0.3*

 SDS during SPECT^#

5.5 [3.3; 7.0]

–

3.0 [0; 5.0]*^{, &}

4.0 [3.0; 9.0])

–

5.0 [3.0; 8.0]

 WMS at stress during DSE

26.8 ± 7.0

24.2 ± 7.3*

23.1 ± 5.8*

26.3 ± 6.5

25.0 ± 5.7

23.5 ± 5.1*

 LVEF at stress during DSE, %

49.8 ± 11.2

54.1 ± 12.3*

56.8 ± 9.4*

51.6 ± 11.0

53.4 ± 11.6

53.7 ± 9.7

 Number of patients with at least moderate ischemia in DSE, n (%)

17 (57)

6 (21)*

5 (18)*

14 (48)

10 (36)

9 (35)

 Number of patients with at least moderate ischemia in SPECT, n (%)

22 (73)

–

12 (46)*

21 (72.4)

–

17 (68)

 ECG changes during stress DSE, n (%)

22 (73)

13 (46)*^{, &}

13 (46)*

19 (66)

21 (75)

16 (62)

 Angina during stress DSE, n (%)

23 (77)

12 (43)*

10 (36)*

18 (62)

13 (46)

11 (42)*

 Global PSS at stress during DSE, %

−15.0 ± 3.2

−13.7 ± 3.0

−14.0 ± 2.3

−15.1 ± 4.5

− 13.7 ± 3.6

−13.6 ± 2.4

 Summed stress score (SSS) during SPECT^#

8.5 [5.3; 12.8]

–

5.0 [2.0; 12.0]*

10.0 [4.0; 15.0]

–

8.0 [3.0; 14.0]

 TPD at stress during SPECT, %^#

13.0 [6.3; 18.8]

–

7.0 [3.0; 17.5]*

15.0 [6.0; 22.0]

–

12.0 [4.0; 20.0]

 TPD at rest during SPECT, %^#

2.0 [0; 7.8]

–

0 [0; 7.0])

2.0 [0; 10.0])

–

3.0 [0; 9.0]

 TPD difference during SPECT, %

7.0 [4.3; 11.0]

–

4.0 [0; 7.0]*^,&

7.0 [5.0; 13.0]

–

7.0 [4.0; 12.0]

 WMS at rest during DSE

23.4 ± 7.8

23.6 ± 7.8

22.6 ± 6.4

23.8 ± 7.0

24.3 ± 6.9

22.8 ± 5.7

 WMSI at rest during DSE

1.4 ± 0.5

1.4 ± 0.5

1.3 ± 0.4

1.4 ± 0.4

1.4 ± 0.4

1.3 ± 0.3

 LVEF at rest during DSE, %

46.5 ± 10.6

47.3 ± 11.0

49.8 ± 8.6*

48.5 ± 9.0

48.2 ± 8.6

48.5 ± 8.1

 Number of positive DSE tests, n (%)

21 (70)

10 (36)*

8 (29)*

20 (69)

13 (46)

11 (4)

 Number of positive SPECT tests, n (%)

28 (93)

–

18 (69)*

28 (96)

–

21 (84)

 Global PSS at rest, %

−14.8 ± 3.4

−13.2 ± 3.8

−13.9 ± 2.7

−14.1 ± 2.2

−13.5 ± 2.6

−13.0 ± 1.9

 SRS during SPECT^#

1.0 [0; 5.8]

–

0 [0; 5.0]

2.0 [0; 7.0]

2.0 [0; 6.0]