Primary endpoints
|
WMSI at stress during DSE
|
1.6 ± 0.4
|
1.4 ± 0.4*
|
1.4 ± 0.3*
|
1.6 ± 0.4
|
1.5 ± 0.3
|
1.4 ± 0.3*
|
SDS during SPECT#
|
5.5 [3.3; 7.0]
|
–
|
3.0 [0; 5.0]*, &
|
4.0 [3.0; 9.0])
|
–
|
5.0 [3.0; 8.0]
|
Secondary endpoints
|
WMS at stress during DSE
|
26.8 ± 7.0
|
24.2 ± 7.3*
|
23.1 ± 5.8*
|
26.3 ± 6.5
|
25.0 ± 5.7
|
23.5 ± 5.1*
|
LVEF at stress during DSE, %
|
49.8 ± 11.2
|
54.1 ± 12.3*
|
56.8 ± 9.4*
|
51.6 ± 11.0
|
53.4 ± 11.6
|
53.7 ± 9.7
|
Number of patients with at least moderate ischemia in DSE, n (%)
|
17 (57)
|
6 (21)*
|
5 (18)*
|
14 (48)
|
10 (36)
|
9 (35)
|
Number of patients with at least moderate ischemia in SPECT, n (%)
|
22 (73)
|
–
|
12 (46)*
|
21 (72.4)
|
–
|
17 (68)
|
ECG changes during stress DSE, n (%)
|
22 (73)
|
13 (46)*, &
|
13 (46)*
|
19 (66)
|
21 (75)
|
16 (62)
|
Angina during stress DSE, n (%)
|
23 (77)
|
12 (43)*
|
10 (36)*
|
18 (62)
|
13 (46)
|
11 (42)*
|
Global PSS at stress during DSE, %
|
−15.0 ± 3.2
|
−13.7 ± 3.0
|
−14.0 ± 2.3
|
−15.1 ± 4.5
|
− 13.7 ± 3.6
|
−13.6 ± 2.4
|
Summed stress score (SSS) during SPECT#
|
8.5 [5.3; 12.8]
|
–
|
5.0 [2.0; 12.0]*
|
10.0 [4.0; 15.0]
|
–
|
8.0 [3.0; 14.0]
|
TPD at stress during SPECT, %#
|
13.0 [6.3; 18.8]
|
–
|
7.0 [3.0; 17.5]*
|
15.0 [6.0; 22.0]
|
–
|
12.0 [4.0; 20.0]
|
TPD at rest during SPECT, %#
|
2.0 [0; 7.8]
|
–
|
0 [0; 7.0])
|
2.0 [0; 10.0])
|
–
|
3.0 [0; 9.0]
|
TPD difference during SPECT, %
|
7.0 [4.3; 11.0]
|
–
|
4.0 [0; 7.0]*,&
|
7.0 [5.0; 13.0]
|
–
|
7.0 [4.0; 12.0]
|
Other tests characteristics
|
WMS at rest during DSE
|
23.4 ± 7.8
|
23.6 ± 7.8
|
22.6 ± 6.4
|
23.8 ± 7.0
|
24.3 ± 6.9
|
22.8 ± 5.7
|
WMSI at rest during DSE
|
1.4 ± 0.5
|
1.4 ± 0.5
|
1.3 ± 0.4
|
1.4 ± 0.4
|
1.4 ± 0.4
|
1.3 ± 0.3
|
LVEF at rest during DSE, %
|
46.5 ± 10.6
|
47.3 ± 11.0
|
49.8 ± 8.6*
|
48.5 ± 9.0
|
48.2 ± 8.6
|
48.5 ± 8.1
|
Number of positive DSE tests, n (%)
|
21 (70)
|
10 (36)*
|
8 (29)*
|
20 (69)
|
13 (46)
|
11 (4)
|
Number of positive SPECT tests, n (%)
|
28 (93)
|
–
|
18 (69)*
|
28 (96)
|
–
|
21 (84)
|
Global PSS at rest, %
|
−14.8 ± 3.4
|
−13.2 ± 3.8
|
−13.9 ± 2.7
|
−14.1 ± 2.2
|
−13.5 ± 2.6
|
−13.0 ± 1.9
|
SRS during SPECT#
|
1.0 [0; 5.8]
|
–
|
0 [0; 5.0]
|
2.0 [0; 7.0]
| |
2.0 [0; 6.0]
|