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Table 4 Multivariate associations of LV EF and GLS

From: Global longitudinal strain is a hallmark of cardiac damage in mitral regurgitation: the Italian arm of the European Registry of mitral regurgitation (EuMiClip)

Dependent VariableCovariateβ coefficientp value
a. in the pooled patients MR
LV EFLV end-diastolic diameter− 0.41<0.0001
LV end-systolic diameter−0.54<0.0001
LV end-diastolic volume−0.40<0.0001
LV end-systolic volume−0.71<0.0001
LA diameter−0.25<0.0001
LAVi−0.38<0.0001
PASP−0.18<0.0001
GLS aLV end-diastolic diameter−0.40<0.0001
LV end-systolic diameter−0.54<0.0001
LV end-diastolic volume−0.40<0.0001
LV end-systolic volume−0.60<0.0001
LA diameter−0.32<0.0001
LAVi−0.41<0.0001
PASP−0.19<0.0001
b. In patients with mild MR
LV EFLV end-diastolic diameter− 0.24<0.0001
LV end-systolic diameter−0.37<0.0001
LV end-diastolic volume−0.22<0.0001
LV end-systolic volume−0.62<0.0001
LA diameter−0.050.417
LAVi−0.22<0.0001
PASP−0.020.735
GLS aLV end-diastolic diameter−0.20<0.0001
LV end-systolic diameter−0.35<0.0001
LV end-diastolic volume−0.25<0.0001
LV end-systolic volume−0.45<0.0001
LA diameter−0.130.04
LAVi−0.23<0.0001
PASP−0.18=0.003
c. In patients with moderate to severe MR
LV EFLV end-diastolic diameter−0.50<0.0001
LV end-systolic diameter−0.59<0.0001
LV end-diastolic volume−0.46<0.0001
LV end-systolic volume−0.72<0.0001
LA diameter−0.210.03
LAVi−0.270.008
PASP−0.170.09
GLS aLV end-diastolic diameter−0.47<0.0001
LV end-systolic diameter−0.59<0.0001
LV end-diastolic volume−0.41<0.0001
LV end-systolic volume−0.61<0.0001
LA diameter−0.25<0.02
LAVi−0.29<0.005
PASP−0.30=0.004
  1. Abbreviations as in Table 4
  2. aValues of GLS considered as “positive” (sign +) to build the associations in order to strengthen their clinical meaning: the higher values the better strain deformation independent on the plus/minus sign