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Table 2 Univariable Cox regression model

From: Biochemical but not imaging parameters are predictive of outcome in septic shock: a pilot study

Variables S group (n = 20) NS group (n = 15) P HR 95%CI
Age, years 56 (46; 68) 64 (54; 73) 0.203 1.027 0.986–1.071
Gender F, n (%) 9 (45%) 5 (33%) 0.563 0.728 0.249–2.131
GSH RB, μmol/L 410 (318; 561) 392 (202; 518) 0.370 0.998 0.995–1.002
GSH TP, μmol/L 4.24 (2.118; 6.228) 2.73 (2.18; 4.18) 0.200 0.833 0.630–1.102
Hcy TP, μmol/L 8.03 (5.92; 14.13) 9.40 (5.48; 15.40) 0.681 1.013 0.952–1.078
CysGly TP, μmol/L 35 (25; 47) 29 (20; 36) 0.454 0.987 0.953–1.022
Cys TP, μmol/L 147 (100; 206) 168 (108; 232) 0.708 1.001 0.998–1.003
MDA, mmol/L 147 (97; 184) 206 (120; 261) 0.074 1.004 1.000–1.008
3-NT nmol/L 12.33 (7.12; 22.65) 12.33 (6.70; 38.10) 0.688 0.999 0.994–1.004
uNEO, μmol/mmol Creat 1.068 (0.528; 1.908) 1.344 (0.822; 3.436) 0.099 1.212 0.964–1.524
IL-6 pg/mL 446 (49; 2540) 1198 (180; 8646) 0.146 1.000 1.000–1.000
sIL-6R pg/mL 31,136 (20,251; 51,166) 33,157 (10,896; 38,651) 0.185 1.000 1.000–1.000
sGP-130 ng/mL 236 (202; 286) 200 (170; 307) 0.685 0.999 0.991–1.006
Ang-1 pg/mL, (500-fold increment) 10,200 (4614; 31,953) 11,062 (4480; 28,900) 0.848 0.999 0.985–1.013
Ang-2 pg/mL, (500-fold increment) 26,950 (10,822; 43,840) 49,048 (33,483; 64,293) 0.003 1.007 1.002–1.012
TnT, ng/L 105 (36; 289) 91 (50; 160) 0.495 1.000 1.000–1.000
NTproBNP, ng/L 19,359 (1991; 31,044) 7558 (3150; 28,820) 0.679 1.000 1.000–1.000
PCT, ng/mL 34 (11; 100) 35 (9; 70) 0.696 0.997 0.983–1.011
PWV, cm/sec 10.3 (8.7; 11.8) 10.8 (8.4; 11.7) 0.931 1.009 0.829–1.228
AX, % 8 (−7; 33) 12 (4; 15) 0.840 1.003 0.974–1.033
VTD, ml 108 (82; 116) 93 (60; 108) 0.220 0.985 0.961–1.009
VTS, ml 39 (32; 49) 39 (29; 61) 0.962 1.001 0.967–1.035
Dtd, mm 49 (41; 54) 45 (40; 49) 0.185 0.926 0.826–1.038
EF, % 55 (40; 64) 55 (39; 61) 0.702 0.992 0.952–1.034
MAPSE, mm 12.5 (12.0; 15.5) 12.5 (11.5; 14.3) 0.779 0.965 0.752–1.239
E, cm/sec 91 (56; 116) 85 (65; 90) 0.466 0.989 0.962–1.018
A, cm/sec 73 (40; 110) 90 (64; 111) 0.472 1.009 0.985–1.032
E/e’ 8.55 (5.75; 12.93) 7.40 (5.95; 13.10) 0.998 1.000 0.833–1.201
Left atrial area, cm2 21 (17; 26) 19 (17; 23) 0.277 0.920 0.792–1.069
TAPSE, mm 20 (16; 23) 19 (15; 23) 0.958 0.997 0.877–1.132
PAPs, mmHg 36 (35; 46) 34 (30; 41) 0.277 0.941 0.844–1.050
  1. Data are expressed as median and interquartile range (I-III). GSH glutathione, Hcy homocysteine, CysGly cysteinilglycine, Cys cysteine, TP total plasma, RB reduced blood, MDA malondialdehyde, 3-NT 3-nitrotyrosine, uNEO urinary neopterin, IL-6 interleukin-6, sIL-6R soluble IL-6 receptor, sGP-130 soluble GP-130, Ang-1 and -2 angiopoietin-1 and-2, TnT Troponin T, NT-proBNP pro B-type natriuretic peptide, PCT pro-calcitonin, PWV pulse wave velocity, AX augmentation index, VTD and VTS telediastolic and telesystolic volumes, EF ejection fraction, MAPSE mitral anular plane excursion, TAPSE tricuspid anular plane excursion, S survivors, NS non-survivors