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Effect of left atrial compliance on pulmonary artery pressure: a case report
Cardiovascular Ultrasound volume 4, Article number: 31 (2006)
Left ventricular diastolic dysfunction, with secondary atrial pressure elevation, is a well-known concept. On the contrary, effect of left atrial compliance on pulmonary pressure is rarely considered.
We report the echocardiographic case of a 9-year-old child who presented severe rheumatic mitral valve regurgitation with a giant left atrium, in contrast to a normal artery pulmonary pressure, testifying of the high left atrial compliance.
Left atrial compliance is an important determinant of symptoms and pulmonary artery pressure in mitral valve disease.
Diastolic heart failure, with marked increase in filling pressures secondary to less compliant ventricles is now well evaluated by new echocardiographic modalities. On the other hand, the effect that the left atrial compliance may have on pulmonary artery pressure is not considered in the daily practice. This concept has been studied especially in mitral stenosis, with a wide range of left atrial pressures despite similar mitral valve areas [1, 2].
We report the case of a 9-year-old asymptomatic girl who presented a 3 on 6 holosystolic murmur, discovered during a cross sectional survey estimating rheumatic heart disease prevalence in schoolchildren of Maputo in Mozambique. The apical impulse was displaced to the left, and a third heart sound and a short diastolic rumble reflect the rapid and voluminous left ventricular filling. No hepatomegaly or other right ventricular failure was found. According to the physical examination, the severe mitral regurgitation was estimated on the trans-thoracic echocardiography, using the PISA method (effective regurgitant orifice of 26 mm2, body mass index of 0.80 m2). Though unfortunately frequent in sub-Saharan Africa, this case draws a particular attention. As seen on the figure, the giant left atrium (73 cm2, 2-D four cavities apical view) contrasted with a normal pulmonary artery pressure estimated on Doppler analysis of the minimal tricuspid regurgitation (Doppler velocity 2.45 m/s, giving a systolic pulmonary artery pressure about 29 mmHg), well correlated with normal convexity of the interventricular septum and low speed of the pulmonary diastolic flow. This profile illustrated the important role that left atrial compliance may have on pulmonary artery pressure.
Pressure decay across the mitral valve depends on mitral valve area, trans-mitral gradient, and atrio-ventricular compliance . Atrio-ventricular compliance can be estimated by Doppler echocardiography from the ratio of mitral valve effective orifice area (calculated by the continuity equation, cm2) and E-wave downslope (cm/s2); according of Flachskampf et al.  the net auriculo-ventricular compliance (Cn) can be calculated as follows: Cn = 1270 × (MVA/E dv/dt) (ml/mmHg) [MVA: mitral valve area in cm2. E dv/dt: E wave downslope of the mitral Doppler signal in cm/sec2]. Atrio-ventricular compliance implies compliance characteristics of the both chambers, atrium and ventricle, as a single unit. When the compliance of either of these chambers is normal, any abnormality of atrio-ventricular compliance reflects abnormal compliance of the other. In case of pure mitral stenosis in young people without additional cardiac pathology, the left ventricle compliance is expected to be normal, and atrio-ventricular compliance is also equivalent to the left atrial compliance, and is a major independent determinant of pulmonary artery pressure measured by catheterization . This low atrial compliance may explain the overestimation of mitral valve area by pressure half-time, in comparison with continuity equation method or planimetry. Moreover, this limitation of the pressure half-time method is well recognized in the setting of percutaneous mitral valvotomy, which induces substantial changes in chamber compliance within a short period of time.
On the opposite, in case of mitral regurgitation, very few data are reported. Echocardiographic atrio-ventricular compliance evaluation may remain difficult because of difficulties to assess to the mitral valve area. In addition, on the contrary of mitral stenosis, in which auriculo-ventricular is essentially dictated by atrial compliance, auriculo-ventricular compliance in mitral regurgitation is more difficult to evaluate. However in mitral regurgitation, atrial size is known to be proportional to its compliance , and may explain a normal pulmonary artery pressure in spite of a chronic severe mitral regurgitation.
In case of severe mitral regurgitation, left atrial size may be a strong predictor of atrial compliance, which is an important determinant of symptoms and pulmonary artery pressure.
Thomas JD, Weyman AE: Fluid dynamics model of mitral valve flow: description with in vitro validation. J Am Coll Cardiol. 1989, 13: 221-223.
Schwammenthal E, Vered Z, Agranat O, Kaplinsky E, Rabinowitz B, Feinberg MS: Impact of atrioventricular compliance on pulmonary artery pressure in mitral stenosis: an exercise echocardiographic study. Circulation. 2000, 102: 2378-2384.
Flachskampf FA, Weyman AE, Guerrero JL, Thomas JD: Calculation of atrioventricular compliance from the mitral flow profile: analytical and in vitro study. J Am Coll Cardiol. 1992, 19: 998-1004.
Li M, Dery JP, Dumesnil JG, Boudreault JR, Jobin J, Pibarot P: Usefulness of measuring net atrioventricular compliance by Doppler echocardiography in patients with mitral stenosis. Am J Cardiol. 2005, 96: 432-435. 10.1016/j.amjcard.2005.03.094
Grimes RY, Levine RA, Walker PG, Yoganathan AP: Dynamics of systolic pulmonary venous flow in mitral regurgitation: mathematical modeling of the pulmonary venous system and atrium. J Am Soc Echocardiogr. 1995, 8: 631-642. 10.1016/S0894-7317(05)80376-1
The author(s) declare that they have no competing interests.
EM, DJ carried out the schoolchildren survey to assess to the prevalence of rheumatic heart disease.
EM, DJ did the echocardiography of this case, analyzed the literature, and wrote the paper.
SV, PO have been involved in the final approval of the version to be published, after analyze of the literature.
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Marijon, E., Jani, D., Voicu, S. et al. Effect of left atrial compliance on pulmonary artery pressure: a case report. Cardiovasc Ultrasound 4, 31 (2006). https://doi.org/10.1186/1476-7120-4-31
- Mitral Regurgitation
- Pulmonary Artery Pressure
- Mitral Stenosis
- Rheumatic Heart Disease
- Diastolic Heart Failure