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Should right ventricle dilatation during exercise have clinical implications in patients with chronic thromboembolic pulmonary hypertension? Case report
© Cotrim et al; licensee BioMed Central Ltd. 2007
- Received: 27 November 2007
- Accepted: 27 December 2007
- Published: 27 December 2007
We describe the case of a 30-year-old female patient with chronic thromboembolic pulmonary hypertension that has an excellent functional capacity under treatment with sildenafil. She did an exercise stress echocardiography that revealed marked right ventricular dilatation during exercise. This information was used for clinical decision and the authors discuss the potential utility of this echocardiographyc sign.
- Pulmonary Arterial Hypertension
- Ventricular Dilatation
- Chronic Thromboembolic Pulmonary Hypertension
- Exercise Echocardiography
Dilatation of right ventricle induced by exercise was first described by Ramanath et al.  in a patient suspected of acute coronary syndrome that after exercise echocardiography revealed right ventricular dilatation and conducted to the correct diagnosis of acute pulmonary thromboembolism. Another patient with chronic thromboembolic pulmonary disease and severe pulmonary arterial hypertension with good response to treatment with bosentan experienced the same phenomenon . We now describe a third case that, in our opinion highlights the utility of exercise echocardiography in this clinical setting.
We report the case of a 30-year-old female patient, with a previous history of chronic pulmonary thromboembolism (PTE) and pulmonary arterial hypertension. She had C and S Protein deficit diagnosed at the first episode of PTE two years ago. She was referred to our Unit for study and treatment.
The distance attained on the six-minute walk test at the first appointment was 516 meters.
The marked changes observed during exercise echocardiography conducted to pulmonary angiography that showed significant alterations in the main branches of the pulmonary artery. The patient was referred to pulmonary endarterectomy.
Treatment of pulmonary arterial hypertension secondary to chronic pulmonary thromboembolic disease is challenging and according to the established guidelines  for pulmonary thromboendarterectomy should be considered for patients with the following criteria: 1) NYHA functional class III or IV symptoms; 2) a preoperative pulmonary vascular resistance greater than 300 dynes.s.cm-5, or 800 dynes.s.cm-5 according to other authors ; 3) surgical accessible thrombus (in main, lobar, or segmental pulmonary arteries), as determined by the appropriate studies; and 4) no severe comorbidities. In addition, some centres have suggested that mean PAP preoperatively should be at least ≥ 40 mmHg.
Our patient clearly doesn't fill the first criteria since under treatment  with sildenafil 25 mg three times daily she has an excellent 6 MWT of 600 meters. However she is young and complains of exertional dyspnoea. Besides exercise echocardiography disclose seriously impaired pulmonary vascular vasodilator reserve. We admit that, despite clinical benignity, the patient still had severely limited pulmonary vasodilator reserve and we performed pulmonary angiography.
In face of the result of the exercise echo we decided to refer the patient to a centre with experience in pulmonary endarterectomy.
The presence or absence of this sign – right ventricular dilatation with exercise – should, in our opinion, be evaluated in patients with chronic pulmonary thromboembolic disease and pulmonary hypertension whenever there are uncertainties about the indication for surgical pulmonary endarterectomy. We think that this sign is probably ominous and should almost certainly reinforce the indication for surgery.
The acute morphologic changes in cardiac anatomy reflect the changes in right and left ventricular haemodynamics,. Echocardiography might be helpful in evaluating the acute hemodynamic response to pulmonary output increase that exercise elicits. The practical utility of this concept for clinical decision is demonstrated in this case report
Written informed consent was obtained for publication from the patient.
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