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Fusion beat in patients with heart failure treated with left ventricular pacing: may ECG morphology relate to mechanical synchrony? A pilot study
© Gianfranchi et al; licensee BioMed Central Ltd. 2008
Received: 29 November 2007
Accepted: 01 January 2008
Published: 01 January 2008
Electrical fusion between left ventricular pacing and spontaneous right ventricular activation is considered the key to resynchronisation in sinus rhythm patients treated with single-site left ventricular pacing.
Use of QRS morphology to optimize device programming in patients with heart failure (HF), sinus rhythm (SR), left bundle branch block (LBBB), treated with single-site left ventricular pacing.
Methods and Results
We defined the "fusion band" (FB) as the range of AV intervals within which surface ECG showed an intermediate morphology between the native LBBB and the fully paced right bundle branch block patterns.
Twenty-four patients were enrolled. Echo-derived parameters were collected in the FB and compared with the basal LBBB condition. Velocity time integral and ejection time did not improve significantly. Diastolic filling time, ejection fraction and myocardial performance index showed a statistically significant improvement in the FB. Interventricular delay and mitral regurgitation progressively and significantly decreased as AV delay shortened in the FB. The tissue Doppler asynchrony index (Ts-SD-12-ejection) showed a non significant decreasing trend in the FB. The indications provided by the tested parameters were mostly concordant in that part of the FB corresponding to the shortest AV intervals.
Using ECG criteria based on the FB may constitute an attractive option for a safe, simple and rapid optimization of resynchronization therapy in patients with HF, SR and LBBB.
Patients with heart failure (HF), low ejection fraction (EF) and left bundle branch block (LBBB) can be treated with cardiac resynchronization therapy (CRT). CRT is an adjunctive treatment currently indicated for patients remaining symptomatic in NYHA class III or IV despite optimal medical therapy [1–3].
Many observational studies, as well as a series of randomized, controlled trials have demonstrated the safety, efficacy and long-term beneficial effects of CRT. These studies have shown statistically significant improvements in quality of life, NYHA functional class ranking, exercise tolerance [4–8] and left ventricular reverse remodelling [8–10]. In addition, reductions in mortality  and hospitalization have recently been demonstrated [4, 5, 7, 8].
Most of the available clinical data have been derived from studies involving permanent biventricular pacing (BIVP). Single-site left ventricular pacing (LVP) confers similar improvements in clinical parameters to BIVP [11–13], even in the long term [14–16]. In comparison with BIVP, single-site LVP is associated with equivalent or better haemodynamic improvement, even during physical exercise .
In patients with left ventricular conduction delay and sinus rhythm, LVP alone significantly increases LV systolic function. Although indications for LVP must still be clear defined, there is growing evidence suggesting that applying LVP is comparable with the BIVP mode in selected HF patients presenting LBBB. Two multi-centre randomized trials [18, 19] have confirmed that there are no substantial differences in response between the two pacing modes. The present availability of devices with separate channels allows the application of LVP while ensuring pacemaker or ICD back-up on the right ventricular lead. The recent European guidelines on cardiac pacing and CRT  state that in selected patients with LBBB and conventional indication to CRT, is reasonable to consider LVP alone.
Electrical fusion between LVP and spontaneous right ventricular activation is considered the key to resynchronisation in sinus rhythm patients treated with single-site LVP [21–26]. Depending on the pacing site and the atrioventricular (AV) interval programmed, atrial synchronous LVP leads to electrical fusion between the intrinsic excitation of the septum and right ventricle, and the stimulated premature excitation of the left ventricular free wall. The degree of electrical coordination depends on the conduction velocity of the intrinsic AV conduction, the prematurity of LVP, LV transmural activation time, the time needed for the paced stimulus to break through into the endocardium, and on the propagation velocity within the myocardial and subendocardial layers.
Electrical fusion can easily be detected through surface ECG: a simple morphological analysis may advise how to programme the device. The aim of this pilot study was to evaluate the use of the QRS morphology of fusion beats to optimise programming in CRT patients with sinus rhythm, LBBB and single-site LVP.
Consecutive patients underwent CRT device implantation in accordance with current guidelines. During post-implantation (>1 month) echocardiographic evaluation, the device was tracked by spontaneous atrial activity thanks to a preserved sinus node function. Ventricular pacing was enabled only in the left ventricle.
On shortening the programmable AV interval by 10 ms steps, we obtained a series of 12-lead ECG showing progressive transition in morphology from LBBB to a completely left preexcited right bundle branch block (RBBB), passing through intermediate QRS of "fusion". The transition was most easily detected in lead V1.
We defined the "fusion band" as the range of AV intervals at which surface ECG showed an intermediate morphology between the native LBBB pattern and the fully paced RBBB pattern.
Patients underwent a conventional echocardiographic examination including M-mode, two-dimensional and Doppler analysis to determine LVEF by means of the biplane Simpson's equation (Vivid 7, GE Vingmed Ultrasound AS, Horten, Norway). Images were obtained during stable haemodynamic conditions by using a 3.5-MHz transducer in standard left parasternal and apical views. The following variables were calculated at each of the patient-specific predefined AV intervals, as mentioned above: LV diastolic filling time (DFT) was measured on the pulsed-wave Doppler of mitral inflow as the time interval from the onset of the E wave to the end of the A wave; mitral regurgitation (MR) was visualized by colour Doppler flow imaging in the 4-chamber apical view and its degree expressed as the percentage of the regurgitant jet area relative to the left atrial size ; acute changes in LV systolic performance were indirectly estimated as either the velocity-time integral (VTI) or the ejection time (ET) calculated on the aortic continuous-wave Doppler spectrogram; to investigate the global LV function, the myocardial performance index (MPI) was also measured [28, 29]. The interventricular mechanical delay was measured on the pulsed-wave Doppler of aortic and pulmonary outflow as the time interval from the onset of the QRS to the beginning of the aortic and pulmonary flow velocity, respectively. Tissue Doppler imaging (TDI) was performed to assess LV dyssynchrony during an off-line analysis of stored images obtained by means of apical 4-chamber, 2-chamber and long-axis views (EchoPac 6.1, GE Vingmed Ultrasound AS). An LV 12-segment model (6 basal and 6 mid segments) was used and LV synchronicity was derived from the standard deviation (SD) of the averaged Ts of all 12 LV segments . All echocardiographic measurements were performed by the same operator and averaged over 3 consecutive cardiac cycles during stable sinus rhythm.
The study had the approval of the Ethics Committee of the Azienda Unità Sanitaria Locale di Ferrara, Via Cassoli 30, 44100 Ferrara (Italy), and informed consent to participate in the investigation was obtained from each patient before enrolment.
All data are expressed as mean ± SD. An intra-patient analysis was performed and the data were compared by means of paired, 2-tailed Student's t-Test. A P value <0.05 was regarded as significant.
Patient Population (24 Pts)
66 ± 10
Males, N (%)
Females, N (%)
QRS width, ms
166 ± 17
NYHA class, N
2.73 ± 0.46
28 ± 5
Post_MI Cardiopathy, N (%)
Valvular Cardiopathy, N (%)
Idiopathic Dilated Cardiomyopathy, N (%)
The fusion band, as assessed through surface ECG analysis, ranged from 95 ± 31 to 189 ± 45 ms. Mean basal QRS width of the patients was 166 ± 17 ms.
To the best of our knowledge this pilot study is the first study to utilize the well-known electrical concept of fusion to guide the optimization of CRT in patients treated with single-site LVP. On the surface electrocardiogram, electrical fusion generates variation in the QRS complex morphology. In our study, we programmed AV intervals in such a way as to modulate the degree of fusion between spontaneous septum/right-ventricular activation and artificial left ventricular stimulation, while keeping the patient's spontaneous atrioventricular conduction unaltered. Optimization of the AV interval, as intended in patients with complete AV block, was not the aim of our study.
CRT is an electrical approach that uses pacing and electrophysiologic principles to improve mechanical performance. When only the LV is stimulated, the interventricular conduction time from left to right allows normal conduction to occur over the right bundle at the longest AV intervals. This results in the fusion of LV pacing and intrinsic conduction, thereby producing biventricular activation by means of single-site pacing.
Initially, the role of intrinsic conduction through the right bundle branch on the haemodynamic effect of left ventricular stimulation was studied in an animal model . The findings of that study indicated that, in canine hearts with experimental LBBB, LV-based pacing can restore LV function in terms of LV dP/dtmax and Systolic Work. Maximum improvement of LV function is consistently obtained on intra-ventricular resynchronization of activation. This requires pacing with AV delays equal to the baseline PQ time. Another experimental study  showed that, at intermediate AV delays, the electrical activation pattern led to a significant reduction in both interventricular and left intraventricular electrical asynchrony.
Subsequently, the relationship between fusion and mechanical efficiency was acutely evaluated in CHF patients by measuring dP/dt . In that study, LV pacing proved superior to BIV pacing, provided that it was associated to ventricular fusion.
While QRS duration is used as a criterion for patient selection, QRS narrowing in response to CRT has proved to be a disappointing index of haemodynamic improvement.
As fusion induces mechanical resynchronization, QRS morphology, rather than duration, may be utilized to identify the desired re-homogenisation.
Recently van Gelder  proposed a method to programme the optimal atrial sensed AV interval as determined from the QRS morphology obtained at the optimal atrial paced AV interval in patients with normal AV conduction and BIVP. This study represents a further confirmation that the morphology of the QRS complex is determined by the activation sequence of the ventricles and identical morphologies represent identical activation sequences. In patients with BIVP, QRS morphology depends on fusion between three propagation waves due to right ventricular pacing, LVP, and intrinsic right bundle conduction .
In patients with single-site LVP, ECG morphology depends on fusion of only two propagation waves due to LVP and intrinsic right bundle conduction. In this setting QRS morphology may provide a simple guide to the proper programming of the device, as progression in the degrees of fusion appears on the surface ECG as variation in the QRS complex .
As it is still unclear which is the most reliable and reproducible echo parameter for evaluating CRT patients, we chose a set of parameters that quantify different aspects of cardiac function in order to explore the different levels of dyssynchrony that may be present in failing hearts. Similarly, it is still unclear whether the optimal haemodynamic effect of CRT coincides with maximal reduction in interventricular or intraventricular asynchrony [9, 23, 26, 33, 34]. Many of the parameters we tested showed a statistically significant improvement, at least in a part of the fusion band, compared with native LBBB: MPI, DFT, interventricular delay, mitral regurgitation and TDI index. ET did not reach significant variations but showed a favourable trend along the fusion band, again in comparison with the basal LBBB. VTI was roughly constant. While all the aspects of cardiac function examined were better in the fusion band than during native LBBB, it was not possible to identify an AV delay at which there was full concordance among the various parameters.
In the shortest part of the band, we observed the largest overlapping among the parameters. Moreover, setting an AV value inside the fusion band may guarantee the persistence of fusion, and thus of the haemodynamic benefits, even during the continuous variation of spontaneous atrioventricular conduction, and even during physical exercise.
Naturally, the approach based on the ECG detection of the fusion band can be adopted only in sinus rhythm patients, as they provide a reliable trigger, in terms of atrial activity, for LV pacing. When possible, the use of single-site LV pacing enables the life of the implanted device to be significantly prolonged.
This approach does not obviate the need for the RV lead, as only patients with LBBB and stable sinus rhythm can benefit from fusion with spontaneous RV activation, and therefore do without RV pacing. Data from the literature show that during atrial fibrillation (AF), provided that LV pacing is not inhibited by high rates, BIV pacing seems superior to single-site LV pacing [35, 36]. As previously documented or new-onset AF is frequent in HF patients, the presence of the RV lead could allow BIV pacing during AF episodes. In this respect, technology could provide us with an algorithm to switch from LV pacing to BIV during AF.
Moreover, patients in whom an implantable defibrillator is indicated need an RV lead for appropriate sensing and defibrillation of the arrhythmia in any case.
Finally, we did not compare LVP with BIVP because this was not the aim of this pilot study. Our objective was to find out an ECG based method to optimize LVP. It seems reasonable that a similar method may be applied even to optimize BIVP, as fusion band may be identified also with this pacing mode.
As patients were evaluated at rest, the study yielded no data regarding the dynamic behaviour of the fusion band during exercise stress testing.
We compared the parameters recorded in the fusion band with native LBBB, but we did not evaluate the extreme condition of complete RBBB corresponding to very early depolarization of the left ventricle. In practice, this evaluation is feasible only in patients with a relatively long PR interval, in whom the programmable AV intervals could be short enough to obtain full capture of the entire myocardium through left pacing, thereby anticipating the spontaneous right bundle branch conduction.
Finally, we did not compare subgroups of patients with ischemic and non-ischemic cardiopathy, owing to the relatively low number of patients in these subgroups.
Using ECG criteria based on the "fusion band" method to optimise single-site LV stimulation seems feasible and reliable. It may constitute an attractive option for the safe, simple and rapid management of devices implanted in patients with heart failure, sinus rhythm and left bundle branch block. Large-scale and long-term studies are needed to validate this method from a clinical point of view.
- Adams KF, Lindenfeld J, Arnold JMO, Baker DW, Barnard DH, Baughman KL, Boehmer JP, Deedwania P, Dunbar SB, Elkayam U, Gheorghiade M, Howlett JG, Konstam MA, Kronenberg MW, Massie BM, Mehra MR, Miller AB, Moser DK, Patterson JH, Rodeheffer RJ, Sackner-Bernstein J, Silver MA, Starling RC, Stevenson LW, Wagoner LE: Executive Summary: HFSA 2006 Comprehensive Heart Failure Practice Guideline. J Cardiac Failure. 2006, 12: 10-38. 10.1016/j.cardfail.2005.12.001.View ArticleGoogle Scholar
- Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, Jessup M, Konstam MA, Mancini DM, Michl K, Oates JA, Rahko PS, Silver MA, Stevenson LW, Yancy CW: ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure). American College of Cardiology. http://content.onlinejacc.org/cgi/reprint/46/6/e1,
- , : Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005). European Heart Journal. 2005, 26: 1115-1140.View ArticleGoogle Scholar
- Cazeau S, Leclercq C, Lavergne T, Walker S, Varma C, Linde C, Garrigue S, Kappenberger L, Haywood GA, Santini M, Bailleul C, Daubert JC: Multisite Stimulation in Cardiomyopathies (MUSTIC) Study Investigators. Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay. N Engl J Med. 2001, 344 (12): 873-80.View ArticlePubMedGoogle Scholar
- Abraham WT, Fisher WG, Smith AL, Delurgio DB, Leon AR, Loh E, Kocovic DZ, Packer M, Clavell AL, Hayes DL, Ellestad M, Messenger J, : Multicenter InSync Randomized Clinical Evaluation. Cardiac resynchronization in chronic heart failure. N Engl J Med. 2002, 346 (24): 1845-53.View ArticlePubMedGoogle Scholar
- Linde C, Leclercq C, Rex S, Garrigue S, Lavergne T, Cazeau S, McKenna W, Fitzgerald M, Deharo JC, Alonso C, Walker S, Braunschweig F, Bailleul C, Daubert JC: Long-term benefits of biventricular pacing in congestive heart failure: results from the MUltisite STimulation in cardiomyopathy (MUSTIC) study. J Am Coll Cardiol. 2002, 40 (1): 111-118.View ArticlePubMedGoogle Scholar
- Bristow MR, Saxon LA, Boehmer J, Krueger S, Kass AD, De Marco T, Carson P, DiCarlo L, DeMets D, White GB, DeVries WD, Feldman MA, : Cardiac Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure. N Engl J Med. 2004, 350: 2140-2150.View ArticlePubMedGoogle Scholar
- Cleland JGF, Daubert JC, Erdmann E, Freemantle N, Gras D, Kappenberger L, Tavazzi L, : The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart Failure. N Engl J Med. 2005, 352: 1539-1549.View ArticlePubMedGoogle Scholar
- Yu CM, Chau E, Sanderson JE, Fan K, Tang MO, Fung WH, Lin H, Kong SL, Lam YM, Hill MR, Lau CP: Tissue Doppler echocardiographic evidence of reverse remodeling and improved synchronicity by simultaneously delaying regional contraction after biventricular pacing therapy in heart failure. Circulation. 2002, 105 (4): 438-445.View ArticlePubMedGoogle Scholar
- Saxon LA, De Marco T, Schafer J, Chatterjee K, Kumar UN, Foster E, : Effects of long-term biventricular stimulation for resynchronization on echocardiographic measures of remodeling. Circulation. 2002, 105 (11): 1304-10.View ArticlePubMedGoogle Scholar
- Blanc JJ, Etienne Y, Gilard M, Mansourati J, Munier S, Boschat J, Benditt DG, Lurie KG: Evaluation of Different Ventricular Pacing Sites in Patients With Severe Heart Failure Results of an Acute Hemodynamic Study. Circulation. 1997, 96: 3273-3277.View ArticlePubMedGoogle Scholar
- Auricchio A, Stellbrink C, Block M, Sack S, Vogt J, Bakker P, Klein H, Kramer A, Ding J, Salo R, Tockman B, Pochet T, Spinelli J, : Effect of pacing chamber and atrioventricular delay on acute systolic function of paced patients with congestive heart failure. Circulation. 1999, 99: 2993-3001.View ArticlePubMedGoogle Scholar
- Nelson GS, Berger RD, Fetics BJ, Talbot M, Spinelli JC, Hare JM, Kass DA: Left ventricular or biventricular pacing improves cardiac function at diminished energy cost in patients with dilated cardiomyopathy and left bundle branch block. Circulation. 2000, 102: 3053-3059.View ArticlePubMedGoogle Scholar
- Blanc JJ, Bertault-Valls V, Fatemi M, Gilard M, Pennec PY, Etienne Y: Midterm Benefits of Left Univentricular Pacing in Patients With Congestive Heart Failure. Circulation. 2004, 109: 1741-1744.View ArticlePubMedGoogle Scholar
- Touiza A, Etienne Y, Gilard M, Fatemi M, Mansourati J, Blanc JJ: Long-Term Left Ventricular Pacing: Assessment and Comparison With Biventricular Pacing in Patients With Severe Congestive Heart Failure. J Am Coll Cardiol. 2001, 38: 1966-1970.View ArticlePubMedGoogle Scholar
- Auricchio A, Stellbrink C, Butter C, Sack S, Vogt J, Misier AR, Bocker D, Block M, Kirkels JH, Kramer A, Huvelle E, : Clinical Efficacy of Cardiac Resynchronization Therapy Using Left Ventricular Pacing in Heart Failure Patients Stratified by Severity of Ventricular Conduction Delay. J Am Coll Cardiol. 2003, 42: 2109-2116.View ArticlePubMedGoogle Scholar
- Riedlbauchova L, Fridl P, Kautzner J, Peichl P: Performance of Left Ventricular Versus Biventricular Pacing in Chronic Heart Failure Assessed by Stress Echocardiography. PACE. 2004, 27: 626-663.View ArticlePubMedGoogle Scholar
- Rao RK, Kumar UN, Schafer J, Viloria E, De Lurgio D, Foster E: Reduced ventricular volumes and improved systolic function with cardiac resynchronization therapy: a randomized trial comparing simultaneous biventricular pacing, sequential biventricular pacing, and left ventricular pacing. Circulation. 2007, 115: 2136-2144.View ArticlePubMedGoogle Scholar
- Gasparini M, Bocchiardo M, Lunati M, Ravazzi PA, Santini M, Zardini M, Signorelli S, Passardi M, Klersy C, : Comparison of 1-year effects of left ventricular and biventricular pacing in patients with heart failure who have ventricular arrhythmias and left bundle-branch block: The Bi vs Left Ventricular Pacing: An International Pilot Evaluation on Heart Failure Patients with Ventricular Arrhythmias (BELIEVE) multicenter prospective randomized pilot study. Am Heart J. 2006, 152: e1-155.e7. 10.1016/j.ahj.2006.04.004.View ArticleGoogle Scholar
- Vardas PE, Auricchio A, Blanc JJ, Daubert JC, Drexler H, Ector H, Gasparini M, Linde C, Morgado FB, Oto A, Sutton R, Trusz-Gluza M: Guidelines for Cardiac Pacing and Cardiac Resynchronization Therapy. The Task Force for Cardiac Pacing and Cardiac Resynchronization Therapy of the European Society of Cardiology. Developed in collaboration with the European Heart Rhythm Association. European Heart J. 2007, 28: 2256-2295. 10.1093/eurheartj/ehm305.View ArticleGoogle Scholar
- Vogt J, Krahnefeld O, Lamp B, Hansky B, Kirkels H, Minami K, Korfer R, Horstkotte D, Kloss M, Auricchio A: Pacing Therapies in Congestive Heart Failure Study Group. Electrocardiographic Remodeling in Patients Paced for Heart Failure. Am J Cardiol. 2000, 86 (suppl): 152K-156K. 10.1016/S0002-9149(00)01347-3.View ArticlePubMedGoogle Scholar
- Auricchio A: Pacing the Left Ventricle: Does Underlying Rhythm Matter?. J Am Coll Cardiol. 2004, 43: 239-240.View ArticlePubMedGoogle Scholar
- Verbeek XA, Vernooy K, Peschar M, Cornelussen RN, Prinzen FW: Intra-ventricular resynchronization for optimal left ventricular function during pacing in experimental left bundle branch block. J Am Coll Cardiol. 2003, 42 (3): 558-567.View ArticlePubMedGoogle Scholar
- Van Gelder BM, Bracke F, Meijer A, Pijls NHJ: The hemodynamic effect of intrinsic conduction during left ventricular pacing as compared to biventricular pacing. J Am Coll Cardiol. 2005, 46: 2305-2310.View ArticlePubMedGoogle Scholar
- Faris OP, Evans FJ, Dick AJ, Raman VK, Ennis DB, Kass DA, McVeigh ER: Endocardial versus epicardial electrical synchrony during LV free. wall pacing. Am J Physiol Heart Circ Physiol. 2003, 285: H1864-H1870.View ArticlePubMedPubMed CentralGoogle Scholar
- Verbeek XAAM, Auricchio A, Yu Y, Ding J, Pochet T, Vernooy K, Kramer A, Spinelli J, Prinzen FW: Tailoring cardiac resynchronization therapy using interventricular asynchrony. Validation of a simple model. Am J Physiol Heart Circ Physiol. 2006, 290: H968-H977.View ArticlePubMedGoogle Scholar
- Spain MG, Smith MD, Grayburn PA, Harlamert EA, DeMaria AN: Quantitative assessment of mitral regurgitation by Doppler color flow imaging: angiographic and hemodynamic correlations. J Am Coll Cardiol. 1989, 13: 585-590.View ArticlePubMedGoogle Scholar
- Tei C, Ling LH, Odge DO, Bailey KR, Oh JK, Rodeheffer RJ, Tajik AJ, Seward JB: New index of combined systolic and diastolic myocardial performance: a simple and reproducible measure of cardiac function – a study in normals and dilated cardiomyopathy. J Cardiol. 1995, 26: 357-366.PubMedGoogle Scholar
- Tei C, Nishimura RA, Seward JB, Tajik AJ: Noninvasive Doppler-Derived Myocardial Performance Index: Correlation with Simultaneous Measurements of Cardiac Catheterization Measurements. J Am Soc Echocardiogr. 1997, 10: 169-178.View ArticlePubMedGoogle Scholar
- Yu CM, Lin H, Zhang Q, Sanderson JE: High prevalence of left ventricular systolic and diastolic asynchrony in patients with congestive heart failure and nomal QRS duration. Heart. 2003, 89 (1): 54-60.View ArticlePubMedPubMed CentralGoogle Scholar
- Van Gelder BM, Brache FA, Van der Voort PH, Meijer A: Optimal Sensed Atrio-Ventricular Interval Determined by Paced QRS Morphology. PACE. 2007, 30: 476-481.View ArticlePubMedGoogle Scholar
- Gianfranchi L, Bettiol K, Pacchioni F, Corbucci G, Alboni P: The fusion band in V1: a simple ECG guide to optimal resynchronization? An echocardiographic case report. Cardiovasc Ultrasound. 2005, 3: 29-View ArticlePubMedPubMed CentralGoogle Scholar
- Kerwin WF, Botvinick EH, O'Connell JW, Merrick SH, DeMarco T, Chatterjee K, Scheibly K, Saxon LA: Ventricular contraction abnormalities in dilated cardiomyopathy: effect of biventricular pacing to correct interventricular dyssynchrony. J Am Coll Cardiol. 2000, 35: 1221-1227.View ArticlePubMedGoogle Scholar
- Sogaard P, Egeblad H, Kim WY, Jensen HK, Pedersen AK, Kristensen BØ, Mortensen PT: Tissue Doppler imaging predicts improved systolic performance and reversed left ventricular remodelling during long-term cardiac resynchronization therapy. J Am Coll Cardiol. 2002, 40: 723-730.View ArticlePubMedGoogle Scholar
- Gasparini M, Auricchio A, Regoli F, Fantoni C, Kawabata M, Galimberti P, Pini D, Ceriotti C, Gronda E, Klersy C, Fratini S, Klein HH: Four-year efficacy of cardiac resynchronization therapy on exercise tolerance and disease progression. The importance of performing atrioventricular junction ablation in patients with atrial fibrillation. J Am Coll Cardiol. 2006, 48: 734-743.View ArticlePubMedGoogle Scholar
- Brignole M, Gammage M, Puggioni E, Alboni P, Raviele A, Sutton R, Vardas P, Bongiorni MG, Bergfeld L, Menozzi C, Musso G: Comparative assessment of right, left, and biventricular pacing in patients with permanent atrial fibrillation. Eur Heart J. 2005, 26 (7): 712-722.View ArticlePubMedGoogle Scholar
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