Study protocol. The subjects ingested two escalating doses of cognac (one dose 1.2 ± 0.1 dl). Each dose of cognac contained ethanol 0.5 mg/kg, and accordingly, the full dose of ethanol was 1.0 g/kg. CFR was measured 30 min after each dose. As a control, CFR was measured in randomized cross-over design without beverage ingestion twice.