- Case report
- Open Access
- Open Peer Review
Right ventricular metastasis of leiomyosarcoma
© Dencker et al; licensee BioMed Central Ltd. 2009
- Received: 22 April 2009
- Accepted: 05 May 2009
- Published: 05 May 2009
Metastatic presentation of leiomyosarcoma in the heart is very rare. We present transthoracic echocardiography and combined PET/CT images of a case with a large right ventricular metastasis of leiomyosarcoma. The patient was placed on cytostatic drugs for palliative purposes, but passed away one month later because of an untreatable ventricular tackycardia.
- Transthoracic Echocardiography
- Cytostatic Drug
- Present Case Report
- Computer Tomography Image
The word sarcoma is derived from the Greek word fleshy substance, and this group of neoplasm constitutes a very heterogeneous group . Leiomyosarcoma of the uterus is a rather uncommon tumor, accounts for only a few percent of all cancers of the uterus, and is associated with poor prognosis [1, 2]. Leiomyosarcoma primarily tend to metastasize to the peritoneal cavity, lung, lymph nodes, or liver . Metastatic manifestations of leiomyosarcoma to the heart are very rare. There are only sporadic case reports of imaging in cases with leiomyosarcoma metastasis to the heart, and none include images from echocardiography and PET/CT [4–8]. The present case report includes transthoracic echocardiography and combined PET/CT images of a large right ventricular metastasis of leiomyosarcoma.
The present case report includes transthoracic echocardiography and combined PET/CT images of a rare case with a large right ventricular metastasis of leiomyosarcoma. Metastatic manifestations of a leiomyosarcoma to the heart are associated with very poor prognosis and our patient passed away only one month later because of an untreatable ventricular tackycardia. The use of a radiopharmaceutical agent such as FDG provides the capability for imaging tumor glucose metabolism, whereas CT images provide anatomical information . The CT images indicated that the tumor was growing through the septum. This could, however, be due to motion artifacts since the image acquisition was not ECG-gated. The image of FDG uptake indicated, for a malignant tumor, moderately elevated uptake in the rim of the tumor, as expected for a leiomyosarcoma , whereas the centre of the tumor displayed no uptake thus suggesting necrosis. Furthermore, there was a significant reduction of glucose uptake in the septum, compared to the lateral wall, which was probably due to tumor growth. This hypothesis was supported by the fact that the contraction of the interventricularseptum was significantly reduced, presumably due to the tumor growth into the interventricularseptum. It is also of interest that the cardiac output of the right ventricle was preserved at rest in our case, despite the fact that almost 50% of the right ventricular lumen was obliterated by the metastasis of the leiomyosarcoma.
The echocardiography diagnosis of a tumor within the heart is not always straightforward . Differential diagnosis that should be considered, apart from metastasis, include primary cardiac tumor -primarily myxoma, vegetation, or thrombus. Assessing the location of the mass combined with echogenicity of the mass, and naturally including patient history often result in a accurate diagnosis. While it has been suggested that contrast echocardiography improves the diagnostic capacity of transthoracic echocardiography examination with respect to differentiating intracardiac masses [11, 12], the evidence for this is scarce. The only reasonably large study was performed by Kirkpatrick and co-workers, who investigated this hypothesis examining a series of 16 patients with cardiac masses . The highest pixel intensity was found in patients with malignant tumor growth, the lowest in patients with thrombus, and middle pixel intensity was found in patients with benign tumors. The overlap in pixel intensity was rather significant. We did not use echo contrast in this patient since the diagnosis was known and the purpose of the echocardiography examination was to evaluate cardiac function. Most physicians considered transesophageal echocardiography is by the method of choice for optimal visualisation of heart morphology. Transesophageal echocardiography was not performed in our patient because of adequate acoustic windows and because the purpose of the examination was to evaluate cardiac function. Cardiac MRI has in recent years emerged as an excellent tool in diagnosing space-occupying lesions within or in the proximity of the heart [13, 14], and has the advantage over CT of not including ionizing radiation or nephrotoxic contrast media. Cardiac MRI could, therefore, play an important role when echocardiography is not conclusive.
There is naturally no consensus or any guidelines for the optimal management of patients with ventricular metastasis of leiomyosarcoma. Surgical resection has been attempted in some cases [4, 5], and this could be an option if the tumor growth is restricted in its growth pattern and if the patient is a candidate for surgery. This was considered unrealistic in our patient due to the infiltrative growth of the tumor in the heart combined with multiple metastases.
- Skubitz KM, D'Adamo DR: Sarcoma. Mayo Clin Proc. 2007, 82: 1409-1432. 10.4065/82.11.1409.View ArticlePubMedGoogle Scholar
- Murakami M, Tsukada H, Shida M, Watanabe M, Maeda H, Koido S, Hirasawa T, Muramatsu T, Miyamoto T, Nasu S, Yasuda S, Kajiwara H, Yasuda M, Ide M: Whole-body positron emission tomography with F-18 fluorodeoxyglucose for the detection of recurrence in uterine sarcomas. Int J Gynecol Cancer. 2006, 16: 854-860. 10.1111/j.1525-1438.2006.00532.x.View ArticlePubMedGoogle Scholar
- Rose PG, Piver MS, Tsukada Y, Lau T: Patterns of metastasis in uterine sarcoma. An autopsy study. Cancer. 1989, 63: 935-938. 10.1002/1097-0142(19890301)63:5<935::AID-CNCR2820630525>3.0.CO;2-9.View ArticlePubMedGoogle Scholar
- Hoy F, Boucher R, Brody A: Uterine leiomyosarcoma with cardiac metastases. Can J Surg. 1988, 31: 418-420.PubMedGoogle Scholar
- Suzuki M, Hamada M, Abe M, Matsuoka H, Shigematsu Y, Sumimoto T, Hiwada K, Osuka Y: Accurate diagnosis of metastatic cardiac leiomyosarcoma with infundibular stenosis and cardiac tamponade by transesophageal echocardiography and Gd-DTPA magnetic resonance imaging–report of a case. Jpn Circ J. 1994, 58: 222-226.View ArticlePubMedGoogle Scholar
- Martin JL, Boak JG: Cardiac metastasis from uterine leiomyosarcoma. J Am Coll Cardiol. 1983, 2: 383-386.View ArticlePubMedGoogle Scholar
- Tominaga K, Shinkai T, Eguchi K, Saijo N, Sasaki Y, Beppu Y, Nishikawa K: The value of two-dimensional echocardiography in detecting malignant tumors in the heart. Cancer. 1986, 58: 1641-1647. 10.1002/1097-0142(19861015)58:8<1641::AID-CNCR2820580811>3.0.CO;2-1.View ArticlePubMedGoogle Scholar
- Cordioli E, Pizzi C, Bugiardini R: Left ventricular metastasis from uterine leiomyosarcoma. Cardiologia. 1999, 44: 1001-1003.PubMedGoogle Scholar
- Devaraj A, Cook GJ, Hansell DM: PET/CT in non-small cell lung cancer staging-promises and problems. Clin Radiol. 2007, 62: 97-108. 10.1016/j.crad.2006.09.015.View ArticlePubMedGoogle Scholar
- Peters PJ, Reinhardt S: The echocardiographic evaluation of intracardiac masses: a review. J Am Soc Echocardiogr. 2006, 19: 230-240. 10.1016/j.echo.2005.10.015.View ArticlePubMedGoogle Scholar
- Lepper W, Shivalkar B, Rinkevich D, Belcik T, Wei K: Assessment of the vascularity of a left ventricular mass using myocardial contrast echocardiography. J Am Soc Echocardiogr. 2002, 15: 1419-1422. 10.1067/mje.2002.124641.View ArticlePubMedGoogle Scholar
- Kirkpatrick JN, Wong T, Bednarz JE, Spencer KT, Sugeng L, Ward RP, DeCara JM, Weinert L, Krausz T, Lang RM: Differential diagnosis of cardiac masses using contrast echocardiographic perfusion imaging. J Am Coll Cardiol. 2004, 43: 1412-1419. 10.1016/j.jacc.2003.09.065.View ArticlePubMedGoogle Scholar
- Sparrow PJ, Kurian JB, Jones TR, Sivananthan MU: MR imaging of cardiac tumors. Radiographics. 2005, 25: 1255-1276. 10.1148/rg.255045721.View ArticlePubMedGoogle Scholar
- Restrepo CS, Largoza A, Lemos DF, Diethelm L, Koshy P, Castillo P, Gomez R, Moncada R, Pandit M: CT and MR imaging findings of malignant cardiac tumors. Curr Probl Diagn Radiol. 2005, 34: 1-11. 10.1067/j.cpradiol.2004.10.003.View ArticlePubMedGoogle Scholar
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