- Case report
- Open Access
- Open Peer Review
"Mushroom cloud": a giant left ventricular pseudoaneurysm after a myocardial infarction due to myocardial bridging – a case report
© Gomes et al; licensee BioMed Central Ltd. 2009
- Received: 05 April 2009
- Accepted: 20 July 2009
- Published: 20 July 2009
Left ventricular pseudoaneurysm is an uncommon complication after transmural myocardial infarction, occurring when a free wall rupture is contained by adhesions of the overlying pericardium preventing acute tamponade. In this report, an unusual case of a 61 year-old male with a giant apical left ventricular pseudoaneurysm after an unnoticed myocardial infarction is presented. On coronary angiogram myocardial bridging of the distal left anterior descending artery was judged to be the infarct related lesion. The echocardiographic diagnosis allowed for a timely surgical intervention which resulted in the patient's full recovery.
- Left Ventricular Cavity
- Myocardial Bridge
- Free Wall Rupture
- Characteristic Imaging Feature
- Silent Myocardial Infarction
Most left ventricular pseudoaneurysms are caused by myocardial infarction. Other causes are cardiac surgery, trauma and infection. After myocardial infarction, left ventricular pseudoaneurysms are usually located in the inferior and posterior basal walls and rarely in the apex. Although the natural history of acquired left ventricular pseudoaneurysms is not perfectly known, it is accepted that the danger of secondary fatal rupture is high for large or expanding pseudoaneurysms or when the diagnosis is made within the first month after the causal event.
Left ventricular pseudoaneurysms may be accidentally detected by routine imaging techniques or during the investigation of symptoms. Distinction of a pseudoaneurysm from a true aneurysm can be difficult but characteristic imaging features are usually effective in reaching a definitive diagnosis [1–3]. Surgical repair of pseudoaneurysms after myocardial infarction is associated with an important, though acceptable, risk of complications with most patients needing concomitant coronary artery bypasses for significant stenoses [4, 5].
We report this case not only because of the unusual features of the left ventricular pseudoaneurym itself (volume, location, "mushroom cloud" appearance), but also because of the rarity of its association with myocardial bridging, the presumed cause of the unnoticed myocardial infarction.
Though left ventricular pseudoaneurysm formation after myocardial infarction has become a less common event in the era of reperfusion therapy, its diagnosis and management still represents a challenge in the light of its potentially catastrophic consequences. The typical clinical scenario is that of persistent or recurrent symptoms, usually of heart failure, chest pain and dyspnea, after an acute ischemic event [6, 7]. In this case, the fact that the myocardial infarction occurred unnoticed made the diagnosis more challenging and precluded the establishment of a time interval between myocardial infarction and the appearance of the pseudoaneurysm.
Echocardiography is a reasonable first diagnostic tool in these cases and, despite the unusual location at the apex, the characteristic imaging features of myocardial wall discontinuity and the presence of a neck smaller than the aneurismal cavity, together with the echogenic pericardial effusion, made it easy to attain a confident diagnosis of pseudoaneurysm, confirmed both during surgery and by the pathologic examination .
Most patients with left ventricular pseudoaneurysms after myocardial infarction have severe multivessel disease on preoperative coronary angiography. In a review by Eren and colleagues, of 14 patients who underwent surgery for left ventricular pseudoaneurysm after myocardial infarction, 10 had 3-vessel disease and 4 had 2-vessel disease . In another report from the Cleveland Clinic, Atik and colleagues, in a series of 30 patients who underwent left ventricular pseudoaneurysm repair after myocardial infarction, found only 2 patients without significant coronary lesions .
When myocardial infarction occurs in patients with normal coronary arteries it is usually considered secondary to coronary spasm or coronary thrombosis. We found a case report of left ventricular pseudoaneurysm caused by coronary spasm that resulted in a silent myocardial infarction .
Myocardial bridging of the coronary arteries, generally considered a benign congenital anomaly, has been reported in association with serious, sometimes fatal cardiovascular events like sudden cardiac death and myocardial infarction [9–11]. Prevalence varies substantially according to the modality and criteria used for detection, being much higher with intravascular ultrasound or at autopsy than with angiography . Myocardial bridges are most commonly located in the left anterior descending artery and although the tunnelled segment is typically spared, the segment proximal to the bridge frequently shows atherosclerotic plaque formation .
In recent years, new diagnostic tools such as quantitative coronary angiography, intravascular ultrasound, and intracoronary Doppler flow velocity measurements available in the catheterization laboratory, have greatly contributed to the understanding of the pathophysiologic mechanisms and etiologic factors of ischemic events associated with myocardial bridging. Although the criteria that justify the link between cardiac events and myocardial bridging have not yet been clearly identified, in this patient several factors placed him at an increased risk for cardiac events associated with myocardial bridging, namely the length and severity of diameter reduction of the coronary artery and the presence of delayed persistence of diastolic diameter reduction .
Myocardial bridging is an uncommon clinical aetiology of heart disease. We report the case of a patient with an apical left ventricular pseudoaneurysm with no major obstructions in the epicardial coronary arteries. An obvious myocardial bridging of the distal left anterior descending artery was considered the most likely cause of the myocardial infarction.
Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Frances C, Romero A, Grady D: Left ventricular pseudoanerysm. J Am Coll Cardiol. 1998, 32 (3): 557-61. 10.1016/S0735-1097(98)00290-3.View ArticlePubMedGoogle Scholar
- Brown SL, Gropler RJ, Harris KM: Distinguishing left ventricular aneurysm from pseudoaneurysm. Chest. 1997, 111 (5): 1403-9. 10.1378/chest.111.5.1403.View ArticlePubMedGoogle Scholar
- Yeo TC, Malouf JF, Oh JK, Seward JB: Clinical profile and outcome in 52 patients with cardiac pseudoaneurysm. Ann Intern Med. 1998, 128 (4): 299-305.View ArticlePubMedGoogle Scholar
- Eren E, Bozbuga N, Toker ME, Keles C, Rabus MB, Yildirim O, Guler M, Balkanay M, Isik O, Yakut C: Surgical treatment of post-infarction left ventricular pseudoaneurysm – A two-decade experience. Tex Heart Inst J. 2007, 34: 47-51.PubMedPubMed CentralGoogle Scholar
- Atik FA, Navia JL, Vega PR, Gonzalez-Stawinski GV, Alster JM, Gillinov AM, Svensson LG, Pettersson BG, Lytle BW, Blackstone EH: Surgical treatment of post-infarction left ventricular pseudoaneurysm. Ann Thorac Surg. 2007, 83: 526-31. 10.1016/j.athoracsur.2006.06.080.View ArticlePubMedGoogle Scholar
- Yip HK, Wu CJ, Chang HW, Wang CP, Cheng CI, Chua S, Chen MC: Cardiac rupture complicating acute myocardial infarction in the direct percutaneous coronary intervention reperfusion era. Chest. 2003, 124: 565-71. 10.1378/chest.124.2.565.View ArticlePubMedGoogle Scholar
- Koçak H, Becit N, Ceviz M, Unlü Y: Left ventricular pseudoaneurysm after myocardial infarction. Heart Vessels. 2003, 18 (3): 160-162. 10.1007/s00380-003-0693-0.View ArticlePubMedGoogle Scholar
- Mahilmaran A, Nayar PG, Sheshadri M, Sudarsana G, Abraham KA: Left ventricular pseudoaneurysm caused by coronary spasm, myocardial infarction, and myocardial rupture. Tex Heart Inst J. 2002, 29: 122-5.PubMedPubMed CentralGoogle Scholar
- Akdemir R, Gunduz H, Emiroglu Y, Uyan C: Myocardial bridging as a cause of acute myocardial infarction: a case report. BMC Cardiovascular Disorders. 2002, 2: 15-10.1186/1471-2261-2-15.View ArticlePubMedPubMed CentralGoogle Scholar
- Bestetti RB, Costa RS, Zucolotto S, Oliveira JS: Fatal outcome associated with autopsy proven myocardial bridging of the left anterior descending coronary artery. Eur Heart J. 1989, 10: 573-6.PubMedGoogle Scholar
- Balamuthusamy S, Kosla S, Benatar D, Arora RR: Myocardial infarction in a young African-American male due to myocardial bridging. Cardiology. 2006, 105 (3): 165-167. 10.1159/000091400.View ArticlePubMedGoogle Scholar
- Tsujita K, Maehara A, Mintz GS, Doi H, Kubo T, Castellanos C, Liu J, Yang J, Oviedo C, Franklin-Bond T, et al: Comparison of angiographic and intravascular ultrasonic detection of myocardial bridging of the left anterior descending coronary artery. Am J Cardiol. 2008, 102: 1608-13. 10.1016/j.amjcard.2008.07.054.View ArticlePubMedGoogle Scholar
- Möhlenkamp S, Hort W, Ge J, Erbel R: Update on myocardial bridging. Circulation. 2002, 106: 2616-22. 10.1161/01.CIR.0000038420.14867.7A.View ArticlePubMedGoogle Scholar
- Bourassa MG, Butnaru A, Lespérance J, Tardif JC: Symptomatic myocardial bridges: overview of ischemic mechanisms and current diagnostic and treatment strategies. J Am Coll Cardiol. 2003, 41: 351-9. 10.1016/S0735-1097(02)02768-7.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.