Energetic performance analysis of staged palliative surgery in tricuspid atresia using vector flow mapping

Background

Staged palliative surgery markedly shifts the balance of volume load on a single ventricle and pulmonary vascular bed. Blalock-Taussig shunt necessitates a single ventricle eject blood to both the systemic and pulmonary circulation. On the contrary, bidirectional cavopulmonary shunt release the single ventricle from pulmonary circulation.

Case presentation

We report a case of tricuspid atresia patient who underwent first palliative surgery and second palliative surgery. Volume loading condition was assessed by energetic parameters (energy loss, kinetic energy) intraoperatively using vector flow mapping. These energetic parameters can simply indicate the volume loading condition.

Conclusion

Vector flow mapping was useful tool for monitoring volume loading condition in congenital heart disease surgery.

There are many types of congenital heart disease collectively referred to as functionally univentricular heart. Patients with a functionally univentricular heart are recommended staged palliative surgery. The first palliative surgery is the Blalock–Taussig shunt (BTS) or pulmonary artery banding, which regulates the pulmonary blood flow. The second palliative surgery is the bidirectional cavopulmonary shunt (BCPS), which is usually performed at the age of around 6 months when pulmonary vascular resistance has sufficiently decreased after birth, but it can also be performed as early as at the age of 2 months [1, 2]. The final palliative surgery is a total cavopulmonary connection, which is usually performed between the age of 2 and 4 years when the pulmonary vascular bed has sufficiently grown. We present a case of staged palliative surgery due to tricuspid atresia in which energetic performance was analyzed using vector flow mapping.

A male infant born at 38 weeks of gestation was diagnosed with tricuspid atresia and hypoplastic right ventricle by a fetal ultrasound scan. Transthoracic echocardiography revealed tricuspid atresia, ventricular septal defect (VSD), pulmonary stenosis, patent ductus arteriosus (PDA), and patent foramen ovale immediately after birth. E-type prostaglandin was prescribed to prevent spontaneous closure of PDA. However, this closure could not be prevented and his oxygen saturation level dropped to 75%. He then underwent BTS and main pulmonary artery division for first palliation at the age of 2 months. A midesophageal four-chamber view using transesophageal echocardiography (TEE) revealed tricuspid atresia, a hypoplastic right ventricle, and VSD (Fig. 1a; Additional files 1 and 2: Video Clips 1 and 2). A midesophageal right ventricle inflow–outflow view using color Doppler imaging demonstrated pulmonary stenosis that caused dissipative flow in the main pulmonary artery before the procedure (Fig. 1b; Additional file 3: Video Clip 3). After the procedure, a midesophageal ascending aortic short-axis view using color Doppler imaging demonstrated an antegrade flow from the completely severed main pulmonary artery to both the right and left pulmonary arteries due to BTS, which connected the brachiocephalic artery to the main pulmonary artery (Fig. 1c; Additional file 4: Video Clip 4). The intraoperative clinical course was uneventful. Pre- and postprocedural hemodynamic parameters were as shown in Table 1. The intraventricular blood flow, energy loss, and kinetic energy of the left ventricular outflow tract were assessed using a vector flow mapping software (Hitachi, Tokyo, Japan) in the midesophageal long-axis view by TEE during the surgery (Figs. 2A, A’, B, B’ and 3; Additional files 5, 6, 7 and 8: Video Clips 5–8). Intraventricular energy loss and kinetic energy of the left ventricular outflow tract were higher in the postoperative phase than in the preoperative phase (Fig. 3). The mean energy loss and kinetic energy increased from 29.4 mW/m to 41.9 mW/m and 35.6 mW/m to 83.8 mW/m, respectively. The patient’s pulmonary blood flow progressively worsened with age; therefore, he underwent BCPS and BTS division for second palliation at the age of 11 months. After the procedure, a midesophageal ascending aortic short-axis view by intraoperative TEE revealed a retrograde flow from the right pulmonary artery to the left pulmonary artery due to BCPS, which connected the superior vena cava with the right pulmonary artery (Fig. 1d; Additional file 9: Video Clip 9). Pre- and postprocedural hemodynamic parameters were as shown in Table 1. Vector flow mapping analysis was performed again for this second palliation (Figs. 2C, C’, D, D’ and 3; Additional files 10, 11, 12 and 13: Video Clips 10–13). Intraventricular energy loss and kinetic energy of the left ventricular outflow tract were lower in the postoperative phase than in the preoperative phase (Fig. 3). The mean energy loss and kinetic energy decreased from 38.3 mW/m to 30.7 mW/m and 127.4 mW/m to 62.0 mW/m, respectively.

Intraoperative transesophageal echocardiographic images. a Midesophageal four-chamber view demonstrating tricuspid atresia, a hypoplastic right ventricle, and VSD. b Midesophageal right ventricle inflow–outflow view using color Doppler imaging demonstrating pulmonary stenosis that caused a dissipative flow in the main pulmonary artery before BTS. c Midesophageal ascending aortic short-axis view using color Doppler imaging demonstrating an antegrade flow from the completely severed main pulmonary artery to both the right and left pulmonary arteries due to BTS, which connected the brachiocepharic artery to the main pulmonary artery. d, Midesophageal ascending aortic short-axis view demonstrating the retrograde flow from the right pulmonary artery to the left pulmonary artery due to the BCPS, which connected the superior vena cava to the right pulmonary artery

Full size image

Vector flow mapping and energy loss images in midesophageal long-axis view. Brightness indicates energy loss. A, Vector flow mapping image before BTS. A’, Energy loss image before BTS. B, Vector flow mapping image after BTS. B′, Energy loss image after BTS. The large bright area indicates increased energy loss compared to Fig. A’ due to the hyperdynamic state. C, Vector flow mapping image before BCPS. Volume loads decrease compared to Fig. B due to the worsened pulmonary blood flow. C′, Energy loss image before BCPS. D, Vector flow mapping image after BCPS. D’, Energy loss image after BCPS. The small bright area indicates decreased energy loss compared to Fig. C′ due to the hypodynamic state

Full size image

Energy loss and kinetic energy graph during one cardiac cycle. Left upper panel, Energy loss graph before and after BTS. Energy loss increased after BTS. Right upper panel, Kinetic energy graph of the left ventricular outflow tract before and after BTS. Kinetic energy increased after BTS. Left lower panel, Energy loss graph before and after BCPS. Energy loss decreased after BCPS. Right lower panel, Kinetic energy graph of the left ventricular outflow tract before and after BCPS. Kinetic energy decreased after BCPS

Full size image

Vector flow mapping is a novel technology that enables the evaluation of intracardiac flow and calculation of energy loss and kinetic energy [3]. This technology uses both color Doppler and speckle tracking images applied to continuity equation from the left and right boundaries. The calculated velocity vectors are integrated according to a weight function [4, 5]. Intracardiac energy loss can be calculated using the following equation [5]:

where μ is the viscosity of blood, u and v are velocity components along the Cartesian axes (x and y), and A is the area of the unit of the grid.

As the equation indicates, energy loss is the total of squared differences between neighboring velocity vectors which were calculated by vector flow mapping method. It increases with a change in the size and direction of the velocity vectors. For example, energy loss is likely to increase due to turbulent flow caused by factors such as aortic stenosis or an unnatural intracardiac vortex due to surgery [6,7,8].

The kinetic energy of the left ventricular outflow tract can be calculated from the following equation:

where ρ is the density of blood (1060 kg/m³), v is the velocity vector of the blood flow, and dL is an increment of the cross-sectional line.

Energy loss is considered to be related to prognosis [9]. It is important to take into account the changes in energy loss and kinetic energy postoperatively because both these parameters show an increase in the hyperdynamic state [6].

Staged palliative surgery markedly shifts the balance of volume load on a single ventricle and pulmonary vascular bed. After BTS, a single ventricle serves an important role in both systemic and pulmonary circulations; this ventricle becomes hyperdynamic and the volume load increases as the hemodynamic parameters indicate in Table 1. Energy loss and kinetic energy increase due to the hyperdynamic state. Conversely, after BCPS, the single ventricle is not involved in pulmonary circulation; it becomes hypodynamic and the volume load decreases as the hemodynamic parameters indicate in Table 1. Energy loss and kinetic energy decrease due to the hypodynamic state [10, 11]. These volume loads are difficult to detect using classic hemodynamic parameters. However, we could detect these volume loads using vector flow mapping in terms of energetic performance. After BTS, the increase in kinetic energy (35.6 mW/m to 83.8 mW/m) exceeded the increase in energy loss (29.4 mW/m to 41.9 mW/m) because the single ventricle was additionally involved in pulmonary circulation. Conversely, after BCPS, the single ventricle became hypodynamic, which decreased both energy loss and kinetic energy. The decrease in kinetic energy (127.4 mW/m to 62.0 mW/m) exceeded the decrease in energy loss (38.3 mW/m to 30.7 mW/m) due to the release from pulmonary circulation. Although energy loss is wasted energy, volume loading condition could be estimated by energy loss combined with kinetic energy.

In the present case, after BTS, the single ventricle became hyperdynamic, which increased both energy loss and kinetic energy. Conversely, after BCPS, the single ventricle became hypodynamic, which decreased both energy loss and kinetic energy. Thus, we demonstrated the change in energetic performance after palliative surgeries.

BCPS:

Bidirectional cavopulmonary shunt

BTS:

Blalock–Taussig shunt

PDA:

Patent ductus arteriosus

TEE:

Transesophageal echocardiography

VSD:

Ventricular septal defect

Funding

This research received no grant from any funding agency.

Availability of data and materials

The datasets generated and analyzed in this study are available from the corresponding author on request.

Affiliations

1. Department of Anesthesiology, Kyoto Prefectural University of Medicine, 465 Kajii Cho, Hirokoji Agaru, Kawaramachi Street, Kamigyo Ward, Kyoto City, Kyoto Prefecture, 602-8566, Japan
   • Mao Kinoshita
   • , Koichi Akiyama
   • , Ayahiro Yamashita
   • , Maki Ishii
   • , Atsushi Kainuma
   •  & Teiji Sawa
2. Department of Cardiovascular Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
   • Keiichi Itatani
   • , Yoshinobu Maeda
   • , Takako Miyazaki
   •  & Masaaki Yamagishi

Contributions

MK made substantial contributions to analyzed data, and drafted the manuscript. KA made substantial contributions to conception and design, acquired and analyzed data, and drafted the manuscript. KI made substantial contributions to conception and design, and analyzing the data. AY made substantial contributions to acquiring and analyzing data. MI made substantial contributions to analyzing data, and revised the manuscript. AK revised the manuscript for intellectual content. YM made substantial contributions to acquiring and analyzing data. TM made substantial contributions to acquiring and analyzing data. MY made substantial contributions to the conception and design, and revised the manuscript for intellectual content. TS revised the manuscript for intellectual content. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Koichi Akiyama.

Ethics approval and consent to participate

Ethics approval and consent to participate was obtained.

Consent for publication

A written informed consent was obtained from the patient’s guardian.

Competing interests

Keiichi Itatani is an endowed chair of Kyoto Prefectural University of Medicine, financially supported by Medtronic Japan and has a stock option of Cardio Flow Design. The other authors declare no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Reprints and Permissions