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Can prenatal diagnosis of parachute mitral valve be achieved? A case report of fetal parachute mitral valve
Cardiovascular Ultrasound volume 20, Article number: 16 (2022)
Abstract
Parachute mitral valve (PMV) is a common form of congenital mitral stenosis and is difficult to diagnose prenatally. This report describes a fetal case of PMV with coarctation of the aorta that was diagnosed at 25 weeks’ gestation by echocardiography and confirmed at autopsy. We describe the ultrasonographic features in this case and present a useful sign for making a prenatal diagnosis of PMV.
Background
Parachute mitral valve (PMV) is a congenital anomaly of the papillary muscles (PMs) and frequently leads to mitral stenosis (MS). Fetal MS has often been reported, but accurate assessment of the anatomy of the PMs is difficult in the fetus [1]. Prenatal diagnosis of PMV is challenging. In this report, we describe a case of fetal PMV that was diagnosed by echocardiography and confirmed to be parachute-like asymmetric mitral valve (PLAMV) at autopsy.
Case presentation
A 31-year-old pregnant woman (gravida 1, para 0) was referred to our hospital for fetal echocardiography (Voluson E10; GE Healthcare, Chicago, IL, USA) at 25 weeks’ gestation. Echocardiographic examination revealed fetal PMV associated with coarctation of the aorta (CoA) (Fig. 1). In the four-chamber view, the mobility of the mitral valve leaflets was obviously limited without thickening and the shape of the mitral valve leaflets and some chordae was similar to “Ω” symbol in diastole (Fig. 1a and Movie). Further tracing demonstrated that all the chordae inserted into the posteromedial PM. The short-axis view of the left ventricle detected the posteromedial PM and did not identify the anterolateral PM (Fig. 1b). These findings led to a diagnosis of PMV. A systematic scan of the fetal heart revealed CoA and a small left ventricle (aortic isthmus, Z score − 3.47; left ventricular end-diastolic dimension, Z score − 2.41; left ventricular inlet length, Z score − 1.82). After a multidisciplinary consultation, including with a pediatric cardiac surgeon, the parents decided to terminate the pregnancy at 30 weeks’ gestation in view of the high surgical risks and difficulties associated with reoperation.
Autopsy of the fetal heart and copy number variation sequencing were performed with the informed consent of the parents. Autopsy revealed that all chordae were connected to the elongated posteromedial PM (Fig. 2a) with narrowing of the interchordal spaces and a decreased diameter at the mitral valve opening. The anterolateral PM was attached to the ventricular wall for its entire length and its tip was located near the mitral valve annulus (Fig. 2b). CoA was confirmed at the same time (Fig. 2c). Therefore, a diagnosis of PLAMV with CoA was established. The copy number variation was normal.
Discussion
PMV is a rare congenital malformation of the mitral valve that mainly involves the PMs. According to the underlying anatomy, two subtypes of PMV have been described [2, 3], namely, “true” PMV, which is characterized by a single PM that receives all chordae, and PLAMV, which has two PMs with unevenly distributed chordae. PLAMV is further divided into three grades according to the degree of uneven distribution of the chordae. The most common form is Grade II, in which a few short chordae are attached to the elongated PM [3]. Grade Ш is the most severe form [3]. The present case was found to have a grade Ш PLAMV with two PMs, one of which received all the chordae, while the other PM was attached by its lateral side to the wall of the left ventricle with the tip located near the mitral valve annulus. Disturbed delamination of the anterior or posterior part of the trabecular ridge from the left ventricular wall, combined with underdevelopment of chordae, seems to be the cause of PLAMV [4]. And “ture” PMV develops when the connection between the posterior and anterior part of the ridge condenses to form a single PM [4]. Although their anatomy and embryonic development are different, there is no obvious difference in the clinical manifestations, treatment, or prognosis between PLAMV and “true” PMV [2, 5]. Therefore, most clinical researchers have considered them to be one category.
PMV usually results in congenital MS and is often associated with multiple levels of left heart obstruction, known as Shone’s syndrome. There is limited information on fetal PMV in the literature, but there have been some isolated reports of MS as a manifestation of Shone’s syndrome [1, 6]. However, congenital MS is a morphologically heterogenous lesion that is classically divided into four anatomic types [7]: typical congenital MS, hypoplastic mitral valve, supramitral valve ring, and PMV. The different types of congenital MS require different treatment strategies and have different prognoses. Although the long-term functional outcome in children with congenital MS is satisfactory, surgical procedures for PMV are more complicated, and repeat repair may be needed [8, 9]. It is important to be able to identify the anatomic type of MS for prenatal counseling of parents with regard to treatment strategies and the prognosis.
Prenatal diagnosis of PMV by ultrasound is challenging, and the condition is usually diagnosed after birth. Fetal MS has often been described, but there are few reports on PMV [1, 6]. A restrictive opening of the mitral valve is an important clue for fetal MS. Further differential diagnosis of MS has great value in terms of prenatal consultation, but is difficult. In both children and adults, the echocardiographic characteristics of PMV include a single PM at the mid-papillary level and parachute leaflets at the basal level in the left ventricular short-axis view, doming of the elongated chords in diastole, and an enlarged left atrium in the four-chamber view [9, 10]. The short-axis view of the left ventricle and the four-chamber view are important when evaluating anomalies of the mitral valve. However, the anatomy of the PMs could not be accurately identified in the fetus [1]. In our case, fetal echocardiography failed to demonstrate the anterolateral PM either in the short-axis view of the left ventricle or in the four-chamber view. Therefore, diagnosis of PMV by observing the anatomy of the PMs is unreliable. However, we found that observing the morphology and movement of the valve leaflets and chordae, especially in the four-chamber view, was useful for prenatal diagnosis of PMV. In PMV, all the chordae are attached to one single PM with marked reduction in the interchordal spaces, which leads to specific limitation of movement of the leaflets, especially at the tips. On ultrasound images in the four-chamber view, parts of the leaflets and converged chordae are shaped like an arched bridge, and the overall mitral valve orifice is shaped like the symbol “Ω” in diastole, which is a key diagnostic clue for PMV. The mitral valve “Ω” sign can also be used to differentiate PMV from typical congenital MS and hypoplastic mitral valve. Ultrasonographic features of typical congenital MS is characterized by thickened and rolled leaflets, thickened and shortened chords, and restrictive opening of the mitral valve [11]. In a hypoplastic mitral valve, all components of the mitral valve are miniature versions of those of a normal valve [11].
Conclusion
We have encountered a case of fetal PMV with CoA that was diagnosed by echocardiography and confirmed at autopsy. The “Ω” sign in a fetal mitral valve is an important clue for diagnosis of PMV. This sign provides a strong basis for the diagnosis of fetal PMV in the second trimester of pregnancy and may help to improve the ability to detect this entity.
Availability of data and materials
The data and materials are available from the corresponding author on reasonable request.
References
Zucker N, Levitas A, Zalzstein E. Prenatal diagnosis of Shone’s syndrome: parental counseling and clinical outcome. Ultrasound Obstet Gynecol. 2004;24:629–32.
Marino BS, Kruge LE, Cho CJ, et al. Parachute mitral valve: morphologic descriptors, associated lesions, and outcomes after biventricular repair. J Thorac Cardiovasc Surg. 2009;137(2):385–93.
Oosthoek PW, Wenink AC, Macedo AJ, Gittenberger-de Groot AC. The parachute-like asymmetric mitral valve and its two papillary muscles. J Thorac Cardiov Sur. 1997;114(1):9–15.
Oosthoek PW, Wenink AC, Wisse LJ, et al. Development of the papillary muscles of the mitral valve: morphogenetic background of parachute-like asymmetric mitral valves and other mitral valve anomalies. J Thorac Cardiovasc Surg. 1998;116(1):36–46.
Delmo Walter EM, Javier M, Hetzer R. Repair of parachute and hammock valve in infants and children: early and late outcomes. Semin Thoracic Surg. 2016;448. https://doi.org/10.1053/j.semtcvs.2016.04.011.
Weber RW, Ayala-Arnez R, Atiyah M, et al. Foetal echocardiographic assessment of borderline small left ventricles can predict the need for postnatal intervention. Cardiol Young. 2013;23:99–107. https://doi.org/10.1017/S1047951112000467.
Ruckman RN, Van Praagh R. Anatomic types of congenitall mitral stenosis: report of 49 autopsy cases with consideration of diagnosis and surgical implications. Am J Cardiol. 1978;42:592–601.
Delmo Walter EM, Hetzer R. Repair for congenital mitral valve stenosis. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2018;21:46–57.
Yuan S-M. Parachute mitral valve: morphology and surgical management. Turk J Thorac Cardiovasc Surg. 2020;28(1):219–26.
Hakim FA, Kendall CB, Alharthi M, et al. Parachute mitral valve in adults—a systematic overview. Echocardiography. 2010;27(5):581–6.
Burbano NH. Congenital Mitral Stenosis. J Cardiothorac Vasc Anesth. 2020;34(8):2272–3.
Acknowledgments
The authors are very grateful to the patient’s parents, who contributed the images in this article. The authors also thank Angela Morben, DVM, ELS, from Liwen Bianji, Edanz Editing China (www.liwenbianji.cn/ac), for editing the English text of a draft of this manuscript.
Funding
This study was supported by the National Key R&D Program of China (2017YFC0211705, 2017YFC0113905), the Key R&D Program of Science and Technology Department of Sichuan Province (2019YFS0403, 2019YFS0037), and the Popularization and Application Project of the Sichuan Health and Family Planning Commission (17PJ415).
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Xiaohui Dai and Jiao Chen wrote the main manuscript text. Xiaohui Dai, Jiao Chen and Fumin Zhao prepared figures and moives. Hanmin Liu and Lin Wu participated in the follow-up of the patient. All authors read and approved the final manuscript.
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We further confirm that the data collection covered in this manuscript that has involved our patient has been approved by the ethics committee of West China Second University Hospital of Sichuan University. And written informed consent was obtained from the parent of the patient.
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Dai, X., Chen, J., Liu, H. et al. Can prenatal diagnosis of parachute mitral valve be achieved? A case report of fetal parachute mitral valve. Cardiovasc Ultrasound 20, 16 (2022). https://doi.org/10.1186/s12947-022-00288-z
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DOI: https://doi.org/10.1186/s12947-022-00288-z